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As it is not naturally present in fruit, vegetables, and grains, vegans may not get sufficient amounts of vitamin B12 in their diet

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Further, long-term use of acid-reducing drugs and the anti-diabetes drug metformin and repeated exposure to nitrous oxide have been implicated in vitamin B 12 deficiency (see Drug interactions)

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The cobalmin molecule can be combine with a cyanide molecule as in cynaocobalmin, a hydroxyl molecule as in hydroxycobalmin, methyl group as in methylcobalmin, or an adenosine molecule as in adenosylcobalmin

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