The infiltration of immune cells such as macrophages, neutrophils, mast cells, B cells, T cells, NKT cells within the adipose tissue, coupled with the overproduction of inflammatory mediators and adipokines (e.g., leptin and lipocalin), adipocyte-derived MCP-1 and hypertrophy of visceral adipocytes, leads to hypoxia, autophagy, and apoptosis (130)
The sample size was 9,340 participants
Mansoor et al, 1993b
Brant WO, Dean RC, Lue TF
Postpartum thyroiditis occurs within 6 months after delivery and runs an identical clinical course(57)
Effects studied in this space are mediated through specific enzymatic pathways rather than one mechanism, and the pharmacology is described in the peer-reviewed literature