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According to the Zepbound label, the most frequent include nausea (24-29%), diarrhea (18-24%), vomiting (8-10%), and constipation (16-17%)

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Why GLP-1 Medications Can Make Symptoms Worse GLP-1 medications can amplify these issues in a few ways: Changes in appetite and eating patterns Increased sensitivity to fullness and pressure Altered breathing patterns due to discomfort Increased abdominal guarding or bracing When breathing mechanics shift and the diaphragm is not moving well, pressure is often redirected outward into the abdomen instead of being managed efficiently within the system

45 Concurrently, there is an ongoing exploration of another class of amylin analogues with affinity for both the AMYRs and the CTR for both preclinical and clinical applications, KBP-336