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Enzymatic oligomerization of GSH results in phytochelatins formation to give a generalized structure of (-Glu-Cys) n -Gly ( n = 211)

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The SURMOUNT-4 trial demonstrated that participants who discontinued tirzepatide after initial weight loss regained significant weight (approximately 14% regain over 52 weeks following randomized withdrawal), while those continuing treatment maintained their weight loss, confirming ongoing medication efficacy