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There are also genetic predispositions that render certain individuals susceptible to developing autoimmune diseases (83) and even after Epstein-Barr virus (EBV) infection (84), such as human leukocyte antigen (HLA) variants (84, 85) that have experienced selective pressures whilst co-evolving with pathogens (86, 87)

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Changes in the structure of the cristae and mitochondrial membranes are concomitant with these alterations, eventually leading to mitochondrial rupture, which impairs energy metabolism and induces myocardial injury (46) (Fig

however, spatial planning remains misaligned with strategic transport objectives