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Diabetes Res Clin Pract (2009) 83(1):e2730
The main MoA is activation of the Nrf2 transcriptional pathway
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Ashwagandha ( Withania somnifera ) is the most extensively studied, with preclinical models showing increased T4 production, and reduced cortisol levels (186)
Bioavailability and pharmacokinetics pose major challenges
Yang M, Pei B, Hu Q et al (2023) Effects of selenium supplementation on concurrent chemoradiotherapy in patients with cervical cancer: a randomized, double-blind, placebo-parallel controlled phase II clinical trial
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