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95% CI, 0.29-0.9) at 6 years and 7.2% vs

Ketamine was initially introduced as an anesthetic and analgesic for medical applications (Domino, 2010)

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This finding has direct implications for research protocol design: most published and structured study designs incorporate a rest period following the active phase to allow receptor sensitivity to normalize before any subsequent research cycle, rather than using continuous, uninterrupted administration

Although we did not directly measure serum or tissue levels of these agents in these mice, both interventions were associated with improvement in systemic AGE-related measures and metabolic indices, consistent with their intended modes of action, and their combination offered limited additional benefit beyond specific endpoints

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