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Consequently, a significant difference of 16S rRNA microbial profiles was noted between low- and high-TMAO producing status ( p = 0.001, R 2 = 0.027) despite a small effect size (Fig

Mechanistically, high-glucose conditions induced robust upregulation of BMP4 and increased phosphorylation of its downstream effectors Smad1/5/9, driving tumorigenic signaling

First, GST weakens the efficacy of chemotherapy drugs by promoting their in vitro extrusion

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the reported rate of gastrointestinal adverse events in clinical trials for Wegovy reached 84.1%, including nausea, diarrhea, and vomiting

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