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Numerous compounds that activate NRF2 through various mechanisms and structural compositions have been identified ( Pharmacological activation of NRF2: KEAP1-inhibitors Thus far, the most common class of NRF2-activators mimic the inhibition of NRF2s cytoplasmic negative regulator KEAP1, an adaptor protein for the CUL3/RBX1 E3 ubiquitin ligase complex, to prevent NRF2 proteasomal degradation (Kobayashi et al., 2004)