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Based upon crystallographic analysis of metformin interaction with known direct targets, such as CYP3A4, computational studies have suggested that there may be as many as 40 proteins that are direct targets for the action of metformin

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Key areas such as the prefrontal cortex and the striatum, including the nucleus accumbens, have been shown to be critical in decision-making and motivational behaviors (14)

Clin Rev Allergy Immunol 52(3):436445