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The resultant ADC displayed high potency in in vitro cell cytotoxicity assays

Similar in vitro analysis of human colon adenocarcinoma cell line Caco-2 demonstrated increased IL-8 production in filter-grown cells 24 h post-introduction of 1 and 10 mM H 2 O 2 (Nmeth et al., 2007)

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The NOX family contributes to ROS generation and subsequent ferroptosis in ovarian and colorectal cancer cells [97,98,99]