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Many important physiological functions, such as the regulation of cell cycle (mitogenesis and apoptosis), are known to be tightly coupled to the induction of controlled episodes of oxidative stress in biological systems

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J Cereb Blood Flow Metab 177:56225641 Lu JYD, Su P, Barber JEM, Nash JE, Le AD, Liu F, Wong AHC (2017) The neuroprotective effect of nicotine in Parkinsons disease models is associated with inhibiting PARP-1 and caspase-3 cleavage