It may point to liver disease, blood disorders or an underlying cancer that has not yet been detected
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doi: 10.1016/j.redox.2013.08.006
Metabolic stress induces GD2 + cancer stem cell-like phenotype in triple-negative breast cancer
When the cellular demand for NAD+ to sustain oxidation exceeds the rate of ATP turnover, particularly in cells exhibiting active aerobic glycolysis, NAD+ regeneration becomes a limiting factor under conditions of compromised mitochondrial respiration