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Furthermore, recent studies have shown that the PKD of JAK2, unlike the other members of the JAK family, exhibits some catalytic activity via autophosphorylation of two critical residues in the JH2SH2 linker region, Ser 523 and Tyr 570 , which play an important role in regulating the activity of the KD (82, 83)

Thrombospondins as key regulators of synaptogenesis in the central nervous system

Vitamin B12 is essential for neurological function, red blood cell formation, and DNA synthesis

Sun et al (98) demonstrated that intracellular lactate overload under prolonged ischemia inactivates the AMPK/NRF2/GPX4 protective axis, thereby promoting myocardial ferroptosis and exacerbating cardiac injury

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This depletion may lead to compromised immunity, increased oxidative stress, and vulnerability to a range of health issues