El gran problema de estos frmacos es que no diferencian entre grasa y msculo, lo que aumenta el riesgo de sarcopenia, es decir, fragilidad, prdida de masa muscular y peor calidad de vida, sobre todo en pacientes de edad avanzada (25)
The nausea is both dose-dependent and time-dependent, meaning higher doses produce more nausea, and symptoms are most prominent during treatment initiation before the body adapts to the medications effects
Also, for patients, they are easy to consume, with increased affordability and accessibility, enhancing the development of the oral medications used in diabetes and obesity
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That means that they stimulate the body to produce and secrete its own growth hormone
PMID: 41380824 Int J Obes Efficacy of GLP-1 analog peptides, semaglutide, tirzepatide, and retatrutide on MC4R deficient obesity and their comparison