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Finally, the biology of non-response and therapeutic resistance - including the role of gut microbiome composition, adipose tissue dysfunction phenotypes, and genetic determinants of drug metabolism - represents a frontier for translational investigation to improve patient outcomes
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Baseline IGF-1 levels before starting treatment are the single strongest predictor of how dramatic the before and after difference will be
The volunteers were randomly assigned to receive semaglutide (up to 2.4 milligrams, the highest dose currently approved for obesity treatment) or placebo over a 72-week period
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Yang et al., 2019
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