The extent of the increase, which seems to be genotype dependent, was about 2-fold at 9 C after 4 months or up to 1.8-fold at 4 C after 7 months 151,152
Tuttavia, con lavanzare dellet, la sua produzione fisiologica diminuisce progressivamente, portando a perdita di tono, comparsa di rughe e riduzione della densit cutanea
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