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Glutathione oral supplements Research on oral glutathione supplements is mixed, largely because the antioxidant is poorly absorbed during digestion

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Instead Grx2, a mitochondrial isoform, exhibits de-glutathionylation activity for peptides and proteins but with a catalytic activity 10-fold lower with respect to Grx1 (Beer et al., 2004

Because it degrades in blood in a pathway involving amino-peptidases, it may not be suitable for people who take medications that inhibit or are metabolized by peptidases (e.g., captopril, a treatment for hypertension).4 Also, based on what we know about other therapeutic peptides, we would say DSIP is contraindicated for women who are pregnant or breastfeeding as well as people with a personal history of cancer