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Bloodbrain barrier breakdown in the aging human hippocampus

First, regarding the applicant's statement that the evidence provided in support of the category of single-use cystoscopes should suffice for a demonstration of substantial clinical improvement, we reiterate that, CMS evaluates transitional pass-through applications using the substantial clinical improvement criterion described at 419.66(c)(2)(i), which requires CMS to determine if the device that has been nominated has demonstrated that it will substantially improve the diagnosis or treatment of an illness or injury or improve the functioning of a malformed body part compared to the benefits of a device or devices in a previously established category or other available treatment. The regulatory provision refers to the device (singular) being compared to a device or devices for purposes of substantial clinical improvement

10.2174/13816128130105 27 DjakovicZ.DjakovicI.CesarecV.MadzaracG.BecejacT.ZukanovicG.et al (2016)

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Test at baseline before starting semaglutide