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When symptoms do occur, they may include: Pelvic pain or discomfort ranging from dull aching to sharp pain, often on one side Bloating or abdominal swelling Pain during intercourse (dyspareunia) Irregular menstrual periods or changes in menstrual flow Difficulty emptying the bladder completely Pressure on the bowel , causing constipation Risk factors for developing ovarian cysts include hormonal imbalances, previous ovarian cysts, endometriosis, pelvic infections, and PCOS

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The use of WhIM-generated impurities derived from the API peptide may be useful for generating suitability controls with both high and low risk of immunogenicity