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The documented handling is to take it soon if several days remain before the next scheduled dose, or skip it otherwise never double up, because two doses close together stacks the incretin effect and reliably provokes GI symptoms

The first day you descend about 15 km to the river, the second day you climb 12 km to Santa Rosa, the third day you climb 8 km to Choquequirao, and the fourth and fifth days you return

References Sosne G, Qiu P, Kurpakus-Wheater M

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical metabolic coenzyme essential for redox reactions, mitochondrial function, and cellular energy generation