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The local mechanisms of these effects are still under investigation, but GLP-1R co-expresses with proteins known to play an important role in appetite, such as prolactin-releasing peptide and tyrosine hydroxylase [42, 43]

Curr Opin Biotechnol

The Phase 3 SYNERGY trial (NCT06859268) will evaluate whether retatrutide can resolve steatohepatitis (liver inflammation) and fibrosis, endpoints that would be required for regulatory approval specifically for liver disease treatment

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The most effective foods to help increase GLP-1 naturally include legumes (lentils and black beans), whole grains like oats and barley, and healthy fats like avocado and extra virgin olive oil

The glucagon receptor component should increase resting energy expenditure