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Ideal candidates might include those who: Have documented binge eating episodes causing significant distress Meet BMI criteria for weight management medications Have not responded adequately to psychological interventions (such as cognitive behavioural therapy) Do not have contraindications to GLP-1 therapy Understand the off-label nature of this indication UK SmPCs for GLP-1 medications note findings of thyroid C-cell tumours in rodent studies, though the relevance to humans remains uncertain

It also follows the approval of Bristol Myers Squibb and 2seventy Bios Abecma in third line multiple myeloma

- Concierge MD, accessed April 23, 2025, Switching From Wegovy To Zepbound: A Guide For Patients - Concierge MD, accessed April 23, 2025, Hitting a Weight Loss Plateau on Ozempic or Wegovy - Verywell Health, accessed April 23, 2025, 7 Proven Strategies to Overcome a Weight Loss Plateau on GLP-1 Drugs, accessed April 23, 2025, Ozempic Plateau: Why Am I Not Losing Weight

Additionally, amylin can delay gastric emptying and inhibit glucagon release from pancreatic alpha cells, exerting weight-loss effects through multiple mechanisms, making it a promising partner for GLP-1

Vitamin D, calcium, and magnesium