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Dosing Protocol A suggested once-weekly approach, with either a gradual or a more aggressive escalation

The skins ability to repair itself also slows down

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5.1.15 Other topical agents Other topical agents including thiamidol, linoleic acid, phytic acid, yeast extract, mulberry extract, rucinol, undecylenoyl phenylalanine, and epidermal growth factors have been reported in previous studies as effective compounds in melasma management (Lee et al., 2002