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The man admitted to a 15 year history of steroid abuse and 3 years of rhGH use

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PLoS Biol 14:e2000016

331,332 In mesial temporal lobe epilepsy or tuberous sclerosis, astrocytes demonstrate a specific form of reactivity characterised by an increased expression of GFAP 333 and morphological atrophy manifested by reduced complexity of arbour and loss of distal leaflets

( Reference Dutta, Seirafi and Halpin 39 ) , although riboflavin deficiency alone did not affect the activities of GPx and GR and increased the content of glutathione in the liver, ethanol administration (which can exacerbate oxidative stress) significantly decreased the activities of these enzymes and the content of glutathione in the liver of riboflavin-deficient rats compared with those in the liver of the riboflavin-sufficient control rats

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