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Traditional SPPS is a batch process: each coupling cycle begins and ends before the next begins, with synthesis reactors that fill, react, drain, and refill across each of the 31 or 39 steps required for a GLP-1 peptide

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Nat Med 23:13621368 Saigusa D, Motoike IN, Saito S, Zorzi M, Aoki Y, Kitamura H, Suzuki M, Katsuoka F, Ishii H, Kinoshita K, Motohashi H, Yamamoto M (2019) Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites

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