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Real-World Data In a registry of 1,200 adults with type 2 diabetes and obesity, 65% reported 2% body weight reduction at six months, and 30% lost 5%

Memory formation was not significantly improved (Faivre and Hlscher, 2013a)

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The article says discontinuation studies show weight regain within weeks to months after stopping, and its table calls this rapid regain that requires ongoing therapy

doi: 10.2337/dc16-0690 28 MathieuCZinmanBHemmingssonJUWooVColmanPChristiansenEet al

Physiol Rev 104(4):15331610 Lin X, Zhou Y, Xue L (2024) Mitochondrial complex I subunit MT-ND1 mutations affect disease progression