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We did not receive any public comments on our proposal to continue to remove claim lines reported with modifier PN from the ratesetting process and are finalizing as proposed

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GHK-Cu activates the TGF-/Smad signaling pathwaythe most potent endogenous stimulator of collagen productionwhile simultaneously enhancing production of connective tissue growth factor (CTGF) and FGF-2 that further amplify collagen expression