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Lactate as a metabolite and a regulator in the central nervous system

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Rapid correction of vitamin B12 deficiency improved mood increased energy levels improved memory/concentration improved cognitive performance improved nerve function, reduction of tingling or numbness in hands or feet improved red blood cell production improved digestive function Contraindications for treatment

At higher doses, some concern exists about pro-inflammatory effects: LL-37 can activate NF-kB pathways, potentially worsening certain inflammatory conditions

Baseline eGFR was 60 mL/min in 87.2% of the pooled study population and mean baseline eGFR was 83.0 mL/min/1.73 m2