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We dont know if they increase cancer risk, which is a real concern since many peptides promote blood vessel growth, which could theoretically feed tumors

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However, excessive PARP1 activation, due to exposure to genotoxic agents, can dramatically reduce NAD + and ATP levels, affecting sirtuin activity and cellular homeostasis and leading to cell death

Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV