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Figure 1 2 Review methodology To carry out this updated review on the anticancer effects of bromelain, published studies were searched in specialized databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar, using the next MeSH terms: Animals, Anticarcinogenic Agents/pharmacology, Antineoplastic Agents/pharmacology, Bromelain/pharmacology, Bromelain/administration and dosage, Bromelain/chemistry, Cell Line, Tumor, Cell Survival/drug effects, Dose-Response Relationship, Drug, Humans, Nanocapsules/administration and dosage, Neoplasms/drug therapy, Neoplasms, Experimental/pathology, Signal Transduction/drug effects, Treatment Outcome
Type 2 diabetes is common in patients with obesity, and obesity increases production of estrogen hormones to abnormal levels, causing further fluctuation in periods and ovulation along with an increased risk of pregnancy complications and miscarriage
Participants initially were randomized 1:1 to receive treatment or placebo for a 14-week period, followed by 52 weeks of open-label treatment with Setmelanotide
Recently, Tekin and elebi 107 reported a significant rise in NF-B levels in testicular tissue following the administration of BPA compared to control groups in male rats
They found: Oxycodone administration produced significant dose-related respiratory depressant effects and pronounced sedation with 1 death each at 60 and 150 mg/kg
