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A comprehensive metabolic evaluation helps distinguish whether combined therapy addresses a genuine biomarker-driven need or represents empirical experimentation

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Segal AW, Abo A.The biochemical basis of NADPH oxidase of phagocytes.Trends in Biochemical Sciences

Inhibition of IGF-IR impairs the repair of radiation-induced double strand breaks and sensitizes cancer cells to radiotherapy [82]

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showed that treatment with WA causes a range of Hsp90 chaperone client proteins to degrade in pancreatic cancer cells, indicating that WA inhibits heat shock proteins [101]