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On the one hand, microbial metabolites such as short-chain fatty acids and secondary bile acids stimulate GLP-1 secretion from intestinal L-cells and modulate its circadian rhythm, linking microbial activity to satiety regulation, glucose control, and fat metabolism (Figure 2, left)

This is largely due to the loss of deep fat pads in the face, which are difficult to restore through diet or exercise alone

By remaining attentive to emerging evidence and addressing these research gaps, the pediatric community can better understand the potential role of GLP-1 receptor agonists in managing pediatric obesity

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Understanding GLP-1s: What It Is and How It Works What is GLP-1