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ChaC1 overexpression can augment apoptosis by activating caspase-3/9, degradation of poly (ADP ribose) polymerase, induction of autophagy, ROS generation, increased intracellular calcium and loss of mitochondrial membrane potential (69)
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This additional step of dissociation is required because effective transduction across all cells within the 3D structure is not yet feasible, making it difficult to preserve the organoids spatial organization and cell-cell interactions
Its essential for preventing tissue damage and maintaining consistent medication absorption." Additional tips include ensuring the skin is completely dry after using an alcohol swab and avoiding areas with scars, tattoos, moles, or any irritation
Contributing factors include: Lack of trained neurologists or movement disorder clinics
