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Two phase 3 trials BLOOM (Behavioral modification and Lorcaserin for Overweight and Obesity Management) and BLOSSOM (Behavioral modification and LOrcaserin Second Study for Obesity Management) evaluated obese and overweight patients to demonstrate the efficacy of lorcaserin (10 mg twice daily) over placebo [83.84]
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166,167 The pathophysiology of diabetic mononeuropathy includes ischemic mechanisms, such as the occlusion of the vasa nervorum leading to nerve infarction, metabolic factors, including hyperglycemia-induced oxidative stress, and the formation of advanced glycation end products, contributing to nerve damage
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