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The standard titration schedule spans 16 weeks, starting with 0.25 mg once weekly, then progressing to 0.5 mg, 1.0 mg, 1.7 mg, and finally 2.4 mg as the maintenance dose

Figure 2 Hypoxanthine is a host-microbial co-metabolite that can be affected by both microbial and host metabolism

PMID: 67 GisondiPDel GiglioMDi FrancescoVZamboniMGirolomoniG

Frequency: one subcutaneous injection each day at a consistent time, titrating up as tolerated over a 12-week cycle

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The results of the report suggest a mental health benefit for this class of drugs beyond diabetes health and weight control