However, indirect factors such as reduced dietary intake from decreased appetite, altered gastric emptying, and concurrent use of metformin may increase the risk of B12 deficiency in some patients
After the formation of an epoxyallylic radical, the enzyme hydroperoxide lyase, which should be more accurately termed a hemiacetal synthase, converts the epoxy intermediate into a vinyl ether and thence to a short-lived hemiacetal, which spontaneously decomposes into two short chain fragments, i.e., cis -3-hexenal and 12oxo- cis -9-dodecenoic acid, though the positions and geometry of the double bonds may change by chemical or enzymatic isomerization
This highlights why patients with progressive fatty liver disease, particularly those advancing towards cirrhosis, require careful assessment of their B12 status and overall nutritional health when symptoms or risk factors are present
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