In the SURMOUNT 1 trial, tirzepatide at doses of 5 mg, 10 mg and 15 mg were evaluated against placebo, with pooled tirzepatide groups resulting in significant decreases in total cholesterol, LDL-C, VLDL-C, FFA, and triglycerides and an increase in HDL-C at week 72 of follow-up [35]
F1000 Res
higher values seen with off-label use at maximum doses
This is consistent with the results of GLP-1 in animal experiments conducted by Burgmaier et al
And by adding the new category of GLP-1 medications, especially for that hard to lose stubborn weight, in lowest effective doses, to our already proven strategies, our patients are now achieving faster, more dramatic, and more sustained weight loss than ever before
Studies in the National Library of Medicine suggest that GLP-1 medications can improve menstrual regularity and ovulation, reduce insulin resistance and androgen levels, and support spontaneous pregnancy after a period of treatment