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Untargeted Metabolomics analysis Untargeted metabolomics profiling was performed by Metabo-Profile (Shanghai, China) following these steps: centrifugation, extraction, evaporation, lyophilization, derivatization, and injection

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The rest of the time (7-24 h) the paracetamol rats survived normally although exhausted ( Table 5, Table 6 )

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Thyroid tumours have been noted in some animal studies of the drugs