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Those receiving 5 mg, 10mg, and 15 mg experienced an average reduction of 7.6 kg (about 17 pounds), 9.3 kg (about 20 pounds), and 11.2 kg (about 25 pounds) respectively

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DEXA substudies across the class suggest somewhere between a quarter and a third of the loss can be lean mass, and the early retatrutide figure sits at the high end of that range, with the usual caveats about what DEXA actually measures

Notably, a more recent study revealed that gomisin A activated the PXR, potentially enhancing bile acid metabolism and efflux while increasing hepatic expression of Cyp3a in mice [19]

Q: What if I miss a dose