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While selenium deficiency is a major etiological factor of Keshan disease (54), the seasonal and annual variation in disease occurrence suggested that other factors, especially an infectious agent, might be involved in addition to selenium deficiency (55)

Food remains in the stomach longer, providing a helpful satiety mechanism and curbing between meal urges

Common use of these medications is likely to decrease complications of metabolic disease, which will lead to some cost savings, although will probably not lower total medical expenses unless the cost of the GLP-1s goes down further

Metabolism 146 , 155639 (2023)

For a detailed comparison of semaglutide versus tirzepatide, including the SURMOUNT-5 data and clinical selection considerations, Meto's GLP-1 Peptides deep dive is the most current synthesis available