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[3] The 1998 UKPDS 34 trial (N=1,704 overweight patients with newly diagnosed type 2 diabetes) published in The Lancet demonstrated that intensive metformin therapy reduced all-cause mortality by 36% and diabetes-related endpoints by 32% compared with diet alone, evidence that forms the clinical backbone of every coverage defense for this drug

10.1093/eurheartj/ehac320 [DOI] [PMC free article] [PubMed] [Google Scholar] 380.Huang, X

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Its often used alongside other diabetes treatments like insulin or sulfonylurea