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In these individuals the most common manifesting symptoms are leukoencephalopathy and peripheral neuropathy

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Qiu, Y.-B

Associations between mitochondrial genetic variation, activation of the immune system, and its effects on neurogenesis and neurotransmission have led some authors to suggest that mitochondrial dysfunction initiates a chain of molecular events leading to key symptoms of neuropsychiatric long COVID, such as depressive mood and cognitive impairment [39, 100, 135]

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