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Data analysed by one-way ANOVA, multiple comparison, Bonferroni post hoc test ( e , f , k and l ) and two-way repeated measures ANOVA to assess main effects of treatment ( b , d , h - j , n and p )

5A, the application of 50 nmol/L exendin-4 caused a gradual increase in [Ca 2+ ] i of the GC in a reversible manner, the F340/F380 ratio reaching a maximum in 4 min

However, the specific pathways or pathways involved are not clear enough and need further research and exploration

Phase 3 TRIUMPH-4: 28.7% at 68 weeks

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In Phase 3 studies, retatrutide has been given as a once-weekly injection, usually starting at 2mg once weekly before increasing gradually every four weeks