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Although the reduction in glycated hemoglobin is greater with the combination, it does not appear to be additive [40]

Corticosteroids promote: Fat redistribution , causing central (truncal) obesity and the characteristic "cushingoid" appearance with prolonged use Fluid retention , leading to weight gain that may not reflect true fat accumulation but can be discouraging Muscle protein breakdown , reducing lean body mass and potentially lowering metabolic rate Insulin resistance , making weight loss more difficult The magnitude of these effects is generally dose- and duration-dependent

Deoxycholic acid, a secondary bile acid, increases cardiac output and blood pressure in rats

The clinical trial results to date are encouraging