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They bind firmly to plasma proteins and are slowly excreted in the urine

Among contributors to the antioxidant defense system are also human blood proteins like albumin, ferritin, transferrin, haptoglobin and ceruloplasmin

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Notably, several studies have shown that IIRI can be significantly mitigated by blocking ferroptosis with exogenous antioxidants such as resveratrol or by promoting GPX4 expression through the activation of transient receptor potential vanilloid 1 (TRPV1) in animal models [9, 10]

When the conversion of propionyl-CoA to succinyl-CoA in the mitochondria fails due to Vitamin B 12 deficiency, elevated blood levels of methylmalonic acid (MMA) occur