tirzepatide and mirena reduces food intake appetite, and affects brain functioning, more than placebo and liraglutide Mirena Dosage Guide

3rd infusion = 100 mg/kg over 16 hours

Apr;132(4):636-42

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According to the FDA prescribing information, the most frequently reported side effects were gastrointestinal in nature, including nausea (occurring in 24-29% of patients), diarrhea (18-23%), constipation (13-17%), vomiting (8-10%), and dyspepsia (7-9%)

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This is a very common experience for people adjusting to significant changes in their diet or medication