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While IGF1 LR3 itself is not carcinogenic, the growth-promoting effects of IGF-1 signaling raise theoretical concerns about long-term exposure

The absence of large-scale, controlled studies specifically addressing semaglutide safety and efficacy in autoimmune disease populations represents a significant knowledge gap

Nutrition, lifestyle, and overall health are factored into every care plan

Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin

Biochem biophy Acta, 1998;1381:351-54

However, these patients should be monitored for any unexpected effects, and dose titration should proceed cautiously