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Mechanistically, CB-839 elevates the levels of intracellular ROS, enhances the movement of Nrf2 into the nucleus, leading to an increase in uridine phosphorylase 1 (UPP1) mRNA expression

The program has adjusted the open period dates to maintain a four-week proposal submission window

Winblad B et al (2016) Defeating Alzheimers disease and other dementias: a priority for European science and society

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Analyses were performed using JMP v.17.0.0