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It focuses on maintaining energy levels and supporting metabolic health without the risk of dropping blood sugar too low

At 20 mg/kg, we observed a 4-fold increase with ~13% gametocytemia

We propose that differential cytokine exposure, intrinsic bioenergetic vulnerability, and bloodbrain barrier integrity could contribute to region-specific susceptibility, although direct CNS profiling will be required to test this hypothesis

GLP-1s, however, may also exert direct hormonal effects as GLP-1 receptors can be found across the hypothalamus-pituitary-ovarian (HPO) axis and influence gonadotropin release and follicle development

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Together, these insights help elucidate the origins of metabolic reprogramming and inform the development of targeted therapeutic strategies (Fig